Disc1 overexpression mouse
WebAug 29, 2024 · DISC1 promotes proliferation of MNSPCs. Bar graphs representing OD values derived from MTS assays at 0, 24, 48, and 72 h and line charts are used to present rates of inhibition in different gene … WebSep 21, 2004 · DISC1 (disrupted-in-schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Disc1 overexpression mouse
Did you know?
WebJul 2, 2016 · As a result, FLAG-mouse DISC1 (mDISC1) was co-immunoprecipitated with mouse SNPH (mSNPH)-Myc ∆1–86 and mSNPH-Myc ∆87–159, but not with mSNPH-Myc ∆401–495. In addition, FLAG-mDISC1 failed to co-immunoprecipitate with either mSNPH-Myc ∆447–455 or mSNPH-Myc ∆481–495 (Fig. 1c ). WebJun 11, 2015 · Overexpression of DISC1 via an adeno-associated virus in the hippocampus reduces the levels of soluble A β 40 and A β 42, the density of A β plaques and, importantly, rescues cognitive deficits...
WebFeb 7, 2014 · DISC1 expression was detected in oligodendrocytes of the mouse corpus callosum at P14 and P70. DISC1 mRNA was expressed in primary cultured rat cortical oligodendrocyte precursor cells and decreased when oligodendrocyte precursor cells were induced to differentiate by PDGF deprivation. WebApr 21, 2015 · WIP1 overexpression in murine granule neuron precursor (GNP) cells enhanced expression of Shh target genes, increased the percentage of cells in S phase, …
WebJul 15, 2010 · Furthermore, the many DISC1 mouse models that have been generated collectively demonstrate that mice with disrupted DISC1 function, particularly during neurodevelopment, display behavioral phenotypes that are consistent with psychiatric disorders such as diminished working memory, increased anxiety/hyperactivity, and … WebJul 17, 2012 · To elucidate DISC1–SR interactions in vivo, we generated a mouse model of selective and inducible expression of mutant DISC1 in …
WebDISC1 was discovered in a Scottish pedigree in which a chromosomal translocation that breaks this gene segregates with psychiatric disorders, mainly depression and schizophrenia. Linkage and association studies in diverse populations support DISC1 as a susceptibility gene to a variety of neuropsychiatric disorders. Many Disc1 mouse models …
WebDifferent mutant DISC1 models induced variable social behavior in mice (53) (54)(55). DISC1 overexpression did not influence social preference in rats. However, social memory was disrupted in ... gissal and associates california condenserWebModels & Biospecimens. Access the right platform for your research needs. JAX knows that health status is of critical importance to successful use of mouse models. The rigorous attention of the JAX team to mouse health … giss acronymWebOct 2, 2013 · Here, we demonstrate that DISC1 associates robustly with trafficking-protein-Kinesin-binding-1 which is, in turn, known to interact with the outer mitochondrial membrane proteins Miro1/2, linking... gissa bebisen baby showerWebApr 4, 2024 · National Center for Biotechnology Information gis saluda countyWebSep 21, 2004 · To obtain an overview of DISC1 expression throughout mouse development, a quantitative Western blotting approach was used. Tissue lysates from mice of age E10.5 to E20.5 and from P1 to P35... giss alWebJan 31, 2024 · Five types of DISC1 models were identified across the studies as follows: (1) transgenic expression of truncated human Disc1 protein with dominant-negative (DN) effect; (2) DISC1... funny girl film wikipediaWebDisrupted-in-Schizophrenia 1 (DISC1) Overexpression and Juvenile Immune Activation Cause Sex- Specific Schizophrenia-Related Psychopathology in Rats Article Full-text … gis saint joseph county