Galangin autophagy induction
WebAutophagy may represent a common cellular response to nanomaterials. In the present study, it was demonstrated that zinc oxide nanoparticle (ZON)-elicited autophagy contributes to tumor cell killing by accelerating the intracellular dissolution of ZONs and reactive oxygen species (ROS) generation. In particular, ZONs could promote Atg5 … WebGalangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity. Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner.
Galangin autophagy induction
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WebAbstract. Galangin, 4H-1-benzopyran-4-one,3,5,7-trihydroxy-2-phenyl or 3,5,7-trihydroxyflavone, is a polyphenolic compound derived primarily from different medicinal … WebJul 27, 2016 · Galangin suppresses proliferation and induces apoptosis and autophagy in hepatocellular carcinoma (HCC) cells, but the precise mechanism is not clear. In this study, we demonstrated that...
WebGalangin can suppress hepatocellular carcinoma (HCC) cell proliferation. In this study, we demonstrated that galangin induced autophagy by activating the transforming growth factor... WebApr 14, 2024 · Background In mouse, it was discovered that resveratrol (Res) enhanced osteoporosis (OP) by boosting osteogenesis. Besides, Res can also have an impact on MC3T3-E1 cells, which are crucial for the control of osteogenesis and thus increase osteogenesis. Although some articles have discovered that Res enhanced autophagy to …
WebJan 29, 2024 · Galangin is a known natural inducer for autophagy, in many cell types, including hepatocellular carcinoma (HCC) , colon cancer , and oesophageal carcinoma … WebSep 27, 2024 · Autophagy is a cellular self-digestion process, which functions in the degradation of misfolded proteins and dysfunctional organelles ( 13 ). Substrates, such as cytoplasmic proteins or organelles, are coated by a bilayer membrane generating a vesicle called an autophagosome.
WebOur results confirmed that galangin could induce autophagy, and a previous study reported that galangin mediated autophagy via a p53-dependent pathway as well as by deacetylation of LC3 by SIRT1 ...
WebGalangin autophagy inducing flavonoid Synonym (s): 3,5,7-Trihydroxyflavone, Norizalpinin Empirical Formula (Hill Notation): C15H10O5 CAS Number: 548-83-4 Molecular Weight: … tool to carve out door hingesWebOct 31, 2024 · In order to determine whether induction of hepatocyte autophagy was the mechanism by which galangin protected against hepatic steatosis, we detected the levels of becline1, LC3-II/LC3-I, mTOR, Atg3, AMPKα1, and phosphorylated AMPKα1 protein expression in both the prevention group (Figure 5A and C) and treatment group (Figure … physio alton community hospitalWebFigure 1 Galangin (GLG) reduced the lipopolysaccharide (LPS)-stimulated induction of the expression of the pro form of matrix metallopeptidase 9 (pro-MMP-9) and cell migration in a rat brain astrocyte cell line (RBA-1). (A) Cells were pretreated with galangin (0.1, 1, or 10 μM) for 1 h and then incubated with 2 μg/mL LPS for 12 or 24 h.The conditioned medium … tool to change folder permissionsWeb2 days ago · Physiological autophagy inducers cause destruction of the cytosolic pool of TP53 leading to autophagy induction [52,53,54]. TP53 also regulates mitophagy. TP53 also regulates mitophagy. tool to bury wire in groundWebGalangin induces autophagy through upregulation of p53 in HepG2 cells. Our results indicate that galangin not only induced apoptosis but also prompted cell autophagy … tool to bury dog fence wireThe green fluorescent protein and LC3 (GFP-LC3) fusion protein provides a useful indicator of autophagy initiation through the evaluation of LC3 dots or punctae. When autophagy occurs, GFP-LC3 foci redistribute from a diffuse pattern to a punctate cytoplasmic pattern (GFP-LC3 punctae) and the … See more The human liver cancer cell line HepG2 was obtained from the American Type Culture Collection (Rockville, Md., USA) and maintained at the Institute of Biochemistry and … See more To induce autophagy, HepG2 cells were treated with 130 μM galangin for 24 hours. For the co-immunoprecipitation experiments, HepG2 cells were treated with 130 μM galangin … See more Galangin (PubChem CID: 5281616) was purchased from Sigma–Aldrich and dissolved in dimethyl sulfoxide (DMSO) before addition to the cell cultures. The final concentration of … See more HepG2 cells were harvested by trypsinization, then washed twice with PBS, fixed with the buffer containing 3% glutaraldehyde and 0.1 M cacodylate and then re-fixed in osmium tetroxide. HepG2 cells were embedded … See more physio am altheimer eckWebGalangin Synonyms: 3,5,7-Trihydroxyflavone, Norizalpinin Empirical Formula (Hill Notation): C15H10O5 CAS Number: 548-83-4 Molecular Weight: 270.24 EC Number: 208-960-4 Product Comparison Guide Use the product attributes below to configure the comparison table. (Select up to 3 total.) Select Attribute Select Attribute Select Attribute tool to capture screenshot scrolling window